Dickmeis C, Kauth L, Commandeur U. From infection to healing: The use of plant viruses in bioactive hydrogels. Wiley Interdiscip Rev Nanomedicine Nanobiotechnology. 2020. doi:10.1002/wnan.1662


Lin YY, Schuphan J, Dickmeis C, Buhl EM, Commandeur U, Fischer H. Attachment of Ultralow Amount of Engineered Plant Viral Nanoparticles to Mesenchymal Stem Cells Enhances Osteogenesis and Mineralization. Adv Healthc Mater. 2020. doi:10.1002/adhm.202001245


Shukla S, Roe AJ, Liu R, et al. Affinity of plant viral nanoparticle potato virus X (PVX) towards malignant B cells enables cancer drug delivery. Biomater Sci. 2020;8(14):3935-3943. doi:10.1039/d0bm00683a



D. H. T. Le, U. Commandeur, N. F. Steinmetz, Presentation and Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand via Elongated Plant Viral Nanoparticle Enhances Antitumor Efficacy ACS Nano 13(2):acsnano.8b09462 (2019) doi:10.1021/acsnano.8b09462.


J. Röder, C. Dickmeis, U. Commandeur, Small, Smaller, Nano: New Applications for Potato Virus X in Nanotechnology. Front. Plant Sci. 10 (2019), doi:10.3389/fpls.2019.00158.


D. H. T. Le, E. Méndez-López, C. Wang, U. Commandeur, M. A. Aranda, N. F. Steinmetz, Biodistribution of Filamentous Plant Virus Nanoparticles: Pepino Mosaic Virus versus Potato Virus X. Biomacromolecules. 20, 469–477 (2019).


V. Vignali, B. S. Miranda, I. Lodoso-Torrecilla, C. A. J. Van Nisselroy, B. J. Hoogenberg, S. Dantuma, F. Hollmann, J. W. De Vries, E. M. Warszawik, R. Fischer, U. Commandeur, P. Van Rijn, Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13. Chem. Commun. 55, 51–54 (2019)


S. Shukla, C. Dickmeis, R. Fischer, U. Commandeur, N. F. Steinmetz, In planta production of fluorescent filamentous plant virus-based nanoparticles in Methods in Molecular Biology (Humana Press, New York, NY, 2018; http://link.springer.com/10.1007/978-1-4939-7808-3_5), vol. 1776, pp. 61–84.


C. Dickmeis, K. Altintoprak, P. van Rijn, C. Wege, U. Commandeur, Bioinspired silica mineralization on viral templates in Methods in Molecular Biology (Humana Press, New York, NY, 2018; http://link.springer.com/10.1007/978-1-4939-7808-3_23), vol. 1776, pp. 337–362.


J. Röder, C. Dickmeis, R. Fischer, U. Commandeur, Systemic infection of Nicotiana benthamiana with Potato virus X nanoparticles presenting a fluorescent iLOV polypeptide fused directly to the coat protein. Biomed Res. Int. 2018, 9328671 (2018).


I. Grigoras, H.-J. Vetten, U. Commandeur, H. Ziebell, B. Gronenborn, T. Timchenko, Nanovirus DNA-N encodes a protein mandatory for aphid transmission. Virology. 522, 281–291 (2018).


I. Lauria, C. Dickmeis, J. Röder, M. Beckers, S. Rütten, Y. Y. Lin, U. Commandeur, H. Fischer, Engineered Potato virus X nanoparticles support hydroxyapatite nucleation for improved bone tissue replacementActa Biomater. 62, 317–327 (2017).


D. H. T. Le, K. L. Lee, S. Shukla, U. Commandeur, N. F. Steinmetz, Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy. Nanoscale. 9, 2348–2357 (2017).


K. L. Lee, A. A. Murray, D. H. T. Le, M. R. Sheen, S. Shukla, U. Commandeur, S. Fiering, N. F. Steinmetz, Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response. Nano Lett. 17, 4019–4028 (2017).


J. Röder, R. Fischer, U. Commandeur, Engineering Potato Virus X Particles for a Covalent Protein Based Attachment of Enzymes. Small. 13 (2017), doi:10.1002/smll.201702151.


J. Röder, R. Fischer, U. Commandeur, Adoption of the 2A Ribosomal Skip Principle to Tobacco Mosaic Virus for Peptide Display. Front. Plant Sci. 8, 1125 (2017).


S. Shukla, J. T. Myers, S. E. Woods, X. Gong, A. E. Czapar, U. Commandeur, A. Y. Huang, A. D. Levine, N. F. Steinmetz, Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers. Biomaterials. 121, 15–27 (2017).


D. H. T. Le, H. Hu, U. Commandeur, N. F. Steinmetz, Chemical addressability of potato virus X for its applications in bio/nanotechnology. J. Struct. Biol. 200, 360–368 (2017).


M. Mühlmann, M. Kunze, J. Ribeiro, B. Geinitz, C. Lehmann, U. Schwaneberg, U. Commandeur, J. Büchs, Cellulolytic RoboLector - towards an automated high-throughput screening platform for recombinant cellulase expression. J. Biol. Eng. 11, 1 (2017).


S. Ece, C. Lambertz, R. Fischer, U. Commandeur, Heterologous expression of a Streptomyces cyaneus laccase for biomass modification applications. AMB Express. 7, 86 (2017).


Petrović D, Frank D, Kamerlin SCL, Hoffmann K, Strodel B. Shuffling Active Site Substate Populations Affects Catalytic Activity: The Case of Glucose Oxidase. ACS Catal. (2017)




K. Uhde-Holzem, M. McBurney, B. D. B. Tiu, R. C. Advincula, R. Fischer, U. Commandeur, N. F. Steinmetz, Production of Immunoabsorbent Nanoparticles by Displaying Single-Domain Protein A on Potato Virus X. Macromol. Biosci. 16, 231–241 (2016).


C. Lambertz, S. Ece, R. Fischer, U. Commandeur, Progress and obstacles in the production and application of recombinant lignin-degrading peroxidases. Bioengineered. 7, 145–154 (2016).


S. Shukla, R. D. Dorand, J. T. Myers, S. E. Woods, N. M. Gulati, P. L. Stewart, U. Commandeur, A. Y. Huang, N. F. Steinmetz, Multiple Administrations of Viral Nanoparticles Alter in Vivo Behavior - Insights from Intravital Microscopy. ACS Biomater. Sci. Eng. 2, 829–837 (2016).


H. Klose, M. Günl;nl, B. Usadel, R. Fischer, U. Commandeur, Cell wall modification in tobacco by differential targeting of recombinant endoglucanase from Trichoderma reesei. BMC Plant Biol. 15, 1–11 (2015).


S. Shukla, N. A. DiFranco, A. M. Wen, U. Commandeur, N. F. Steinmetz, To Target or Not to Target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles Based on Potato virus X. Cell. Mol. Bioeng. 8, 433–444 (2015).


P. Van Rijn, L. S. Van Bezouwen, R. Fischer, E. J. Boekema, A. Böker, U. Commandeur, Virus-SiO2and virus-SiO2-Au hybrid particles with tunable morphology. Part. Part. Syst. Charact. 32, 43–47 (2015).


K. Uhde-Holzem, R. Fischer, U. Commandeur, Altering the function and properties of plant viral assemblies via genetic modification in RSC Smart Materials, A. Boker, P. van Rijn, Eds. (The Royal Society of Chemistry, RSC Smart., 2015), vols. 2015-Janua, pp. 73–103.


K. L. Lee, S. Shukla, M. Wu, N. R. Ayat, C. E. El Sanadi, A. M. Wen, J. F. Edelbrock, J. K. Pokorski, U. Commandeur, G. R. Dubyak, N. F. Steinmetz, Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater. 19, 166–179 (2015).


C. Dickmeis, M. M. A. Honickel, R. Fischer, U. Commandeur, Production of Hybrid Chimeric PVX Particles Using a Combination of TMV and PVX-Based Expression Vectors. Front. Bioeng. Biotechnol. 3, 189 (2015).


J. Klinger, R. Fischer, U. Commandeur, Comparison of Thermobifida fusca Cellulases Expressed in Escherichia coli and Nicotiana tabacum Indicates Advantages of the Plant System for the Expression of Bacterial Cellulases. Front. Plant Sci. 6, 1047 (2015).


S. Rettcher, F. Jungk, C. Kühn, H. J. Krause, G. Nölke, U. Commandeur, R. Fischer, S. Schillberg, F. Schröper, Simple and portable magnetic immunoassay for rapid detection and sensitive quantification of plant viruses. Appl. Environ. Microbiol. 81, 3039–3048 (2015).


Lin Q, Chauvistré H, Costa IG, Gusmao EG, Mitzka S, Hänzelmann S, Baying B, Klisch T, Moriggl R, Hennuy B, Smeets H, Hoffmann K, Benes V, Seré K, Zenke M. Epigenetic program and transcription factor circuitry of dendritic cell development. Nucleic Acids Res. (2015)


Kupper MB, Herzog K, Bennink S, Schlömer P, Bogaerts P, Glupczynski Y, Fischer R, Bebrone C, Hoffmann KM. The three-dimensional structure of VIM-31--a metallo-β-lactamase from Enterobacter cloacae in its native and oxidized form. FEBS J. (2015)


K. L. Lee, K. Uhde-holzem, R. Fischer, U. Commandeur, N. F. Steinmetz, Genetic Engineering and Chemical Conjugation of Potato Virus X in Virus Hybrids as Nanomater. Methods Protoc. Methods Mol. Biol. 1108, 3–21 (2014).


K. L. Lee, K. Uhde-Holzem, R. Fischer, U. Commandeur, N. F. Steinmetz, Genetic engineering and chemical conjugation of potato virus X. Methods Mol. Biol. 1108, 3–21 (2014).


S. Shukla, A. M. Wen, U. Commandeur, N. F. Steinmetz, Presentation of HER2 epitopes using a filamentous plant virus-based vaccination platform. J. Mater. Chem. B. 2, 6249–6258 (2014).


M. Garvey, J. Klinger, H. Klose, R. Fischer, U. Commandeur, Expression of Recombinant Cellulase Cel5A from Trichoderma reesei in Tobacco Plants. J. Vis. Exp., e51711 (2014).


S. Shukla, A. M. Wen, N. R. Ayat, U. Commandeur, R. Gopalkrishnan, A. M. Broome, K. W. Lozada, R. A. Keri, N. F. Steinmetz, Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine. 9, 221–235 (2014).


C. Dickmeis, R. Fischer, U. Commandeur, Potato virus X-based expression vectors are stabilized for long-term production of proteins and larger inserts. Biotechnol. J. 9, 1369–1379 (2014).


F. Jansen, B. Gillessen, F. Mueller, U. Commandeur, R. Fischer, F. Kreuzaler, Metabolic engineering for p-coumaryl alcohol production in Escherichia coli by introducing an artificial phenylpropanoid pathway. Biotechnol. Appl. Biochem. 61, 646–654 (2014).


S. Shukla, C. Dickmeis, A. S. Nagarajan, R. Fischer, U. Commandeur, N. F. Steinmetz, Molecular farming of fluorescent virus-based nanoparticles for optical imaging in plants, human cells and mouse models. Biomater. Sci. 2, 784–797 (2014).


C. Lambertz, M. Garvey, J. Klinger, D. Heesel, H. Klose, R. Fischer, U. Commandeur, Challenges and advances in the heterologous expression of cellulolytic enzymes: A review. Biotechnol. Biofuels. 7, 135 (2014).


Herzog K, Bracco P, Onoda A, Hayashi T, Hoffmann K, Schallmey A. Enzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation. Acta Crystallogr D Biol Crystallogr. (2014)


Abnaof K, Mallela N, Walenda G, Meurer SK, Seré K, Lin Q, Smeets B, Hoffmann K, Wagner W, Zenke M, Weiskirchen R, Fröhlich H. TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Syst Biol. (2014)



M. Garvey, H. Klose, R. Fischer, C. Lambertz, U. Commandeur, Cellulases for biomass degradation: Comparing recombinant cellulase expression platforms. Trends Biotechnol. 31, 581–593 (2013).


R. Ostafe, R. Prodanovic, U. Commandeur, R. Fischer, Flow cytometry-based ultra-high-throughput screening assay for cellulase activity. Anal. Biochem. 435, 93–98 (2013).


J. Viell, H. Wulfhorst, T. Schmidt, U. Commandeur, R. Fischer, A. Spiess, W. Marquardt, An efficient process for the saccharification of wood chips by combined ionic liquid pretreatment and enzymatic hydrolysis. Bioresour. Technol. 146, 144–151 (2013).


Bebrone C, Bogaerts P, Delbrück H, Bennink S, Kupper MB, Rezende de Castro R, Glupczynski Y, Hoffmann KM. GES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrob Agents Chemother. (2013)


Walenda G, Abnaof K, Joussen S, Meurer S, Smeets H, Rath B, Hoffmann K, Fröhlich H, Zenke M, Weiskirchen R, Wagner W. TGF-beta1 does not induce senescence of multipotent mesenchymal stromal cells and has similar effects in early and late passages. PLoS One. (2013)


H. Klose, J. Röder, M. Girfoglio, R. Fischer, U. Commandeur, Hyperthermophilic endoglucanase for in planta lignocellulose conversion. Biotechnol. Biofuels. 5, 63 (2012).


A. M. Zakri, A. Ziegler, U. Commandeur, R. Fischer, L. Torrance, In vivo expression and binding activity of scFv-RWAV, which recognizes the coat protein of tomato leaf curl New Delhi virus (family Geminiviridae). Arch. Virol. 157, 1291–1299 (2012).

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